منابع مشابه
Pause locally, splice globally.
Most eukaryotic protein-coding transcripts contain introns, which vary in number and position along the transcript body. Intron removal through pre-mRNA splicing is tightly linked to transcription by RNA polymerase II as it translocates along each gene. Here, we review recent evidence that transcription and splicing are functionally coupled. We focus on how RNA polymerase II elongation rates im...
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Enhancers have been intensely studied as the sequences determining spatial and temporal gene expression during development. Lagha et al. now put the focus back on the promoter as the critical element coordinating gene expression across a cell population.
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The movement of RNA polymerase (RNAP) during transcription elongation is modulated by DNA-encoded elements that cause the elongation complex to pause. One of the best-characterized pause sequences is a binding site for the σ(70) initiation factor that induces pausing at a site near lambdoid phage late-gene promoters. An essential component of this σ(70)-dependent pause is the elemental pause si...
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Humans live in harmony with much of the microbial world, thanks to a sophisticated immune system. As the first line of defense, macrophages engulf, digest, and display foreign material, then recruit specialists to eliminate potential threats. Yet infiltrators exist: certain fungi, viruses, parasites, and bacteria thrive within sentinel macrophages. By scrutinizing the life styles of these shrew...
متن کاملA Lattice-based Approach to Automatic Filled Pause Insertion
This paper describes a novel method for automatically inserting filled pauses (e.g., UM) into fluent texts. Although filled pauses are known to serve a wide range of psychological and structural functions in conversational speech, they have not traditionally been modelled overtly by state-of-the-art speech synthesis systems. However, several recent systems have started to model disfluencies spe...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2010
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2010.11.019